张小雪，女，1984 年 11 月生，湖北武汉人，中共党员，博士，副教授，硕导。

一、教育经历

2003.09-2007.06 华中农业大学 动物科学 学士

2007.09-2010.06 华中农业大学 动物遗传育种与繁殖 硕士 

2015.09-2019.06 兰州大学 动物遗传育种与繁殖 博士

二、研究方向

研究方向：绵羊分子育种与功能基因组

承担的项目：

1. 国家自然科学基金，基于整合组学策略解析挖掘绵羊多肋性状关键基因和功能突变，主持，2025-2028

2. 国家重点研发计划青年科学家项目任务，绵羊饲料效率的遗传基础及表观遗传调控机制解析，主持，2022-2027

3. 甘肃省科技重大专项课题，对标双碳目标的节粮低脂高繁肉羊新品种选育，主持，2022-2025

4. 甘肃省重点研发计划项目，适于肉羊集约化舍饲的高效杂交模式研究与示范，主持，2021-2023

5. 伏羲青年英才，宿主基因组与瘤胃微生物互作调控绵羊重要经济性状的分子机理，主持，2020-2025

6. 国家自然科学基金，宿主基因-瘤胃微生物互作对绵羊剩余采食量调控的分子机理，主持，2018-2021

7. 学科建设专项基金，绵羊宿主基因组与消化道微生物，主持，2018-2020

8. 盛彤笙科技创新基金，绵羊STMN2基因的克隆及其功能的初步研究，主持，2016-2018

三、教育教学

给本科生讲授《普通动物学》、《专业英语》、《特种经济动物生产学》 等课程

四、荣誉称号

甘肃农业大学“伏羲青年英才”

甘肃省优秀硕士论文指导教师（2023）

五、社会兼职

甘肃省第三次全国畜禽遗传资源普查技术专家组成员

六、代表性成果

1. 期刊论文

[1] Jia Liu, Wenxin Zheng, Weimin Wang, Xiaobin Yang, Yongliang Huang, Panpan Cui, Zongwu Ma, Xiwen Zeng, Rui Zhai, Xiuxiu Weng, Weiwei Wu, Xiaoxue Zhang*. Identification of AGO2 and PLEC genes polymorphisms in Hu sheep and their relationship with body size traits. Anim Biotechnol. 2024 Nov;35(1):2295926. (IF=3.7)

[2] Lijuan He, Weimin Wang, Xiaojuan Wang, Deyin Zhang, Yukun Zhang, YuanZhao, Liming Zhao, Xiaolong Li, Jiangbo Cheng, Dan Xu, Zongwu Ma, XiaobinYang, Zhiqiang Huang, Youxin Cai, Xiaoqiang Liu, Zhanyu Chen, Xiuxiu Weng, Changchun Lin, Ping Gong* & Xiaoxue Zhang*. Identification of the FGB gene polymorphism and analysis of its association with fat deposition traits in Hu sheep. Anim Biotechnol. 2024 Nov;35(1):2344207. (IF=1.7)

[3] Xiaobin Yang, Jianghui Wang, Jiangbo Cheng, Deyin Zhang, Kai Huang, Yukun Zhang, Xiaolong Li, Yuan Zhao, Liming Zhao, Dan Xu, Zongwu Ma, Jia Liu, Zhiqiang Huang, Chong Li, Huibin Tian, Xiuxiu Weng, Weimin Wang*, Xiaoxue Zhang*. Relationship between sheep feces scores and gastrointestinal microorganisms and their effects on growth traits and blood indicators. Front Microbiol. 2024 Feb 14;15:1348873. (IF=4)

[4] Zongwu Ma, Weimin Wang, Deyin Zhang, Xinji Wang, Shirong Li, Liming Zhao, Yukun Zhang, Yuan Zhao, Xiaolong Li, Changchun Lin, Jianghui Wang, Jiangbo Cheng, Dan Xu, Xiaobin Yang, Yongliang Huang, Panpan Cui, Jia Liu, Xiwen Zeng, Rui Zhai, Zhiqiang Huang, Xiuxiu Weng, Xiaoxue Zhang*. Polymorphism in IGFALS gene and its association with scrotal circumference in Hu lambs. Anim Biotechnol. 2024 Nov;35(1):2295928. (IF=3.7)

[5] Zongwu Ma, Weimin Wang, Deyin Zhang, Yukun Zhang, Yuan Zhao, Xiaolong Li, Liming Zhao, Jiangbo Cheng, Dan Xu, Xiaobin Yang, Jia Liu, Lijuan He, Zhanyu Chen, Ping Gong*, Xiaoxue Zhang*. Polymorphisms of PLIN1 and MOGAT1 genes and their association with feed efficiency in Hu sheep. Gene. 2024 Mar 1;897:148072. (IF=3.5)

[6] Dan Xu, Jiangbo Cheng, Deyin Zhang, Kai Huang, Yukun Zhang, Xiaolong Li, Yuan Zhao, Li ming Zhao, Jianghui Wang, Changchun Lin, Xiaobin Yang, Rui Zhai, Panpan Cui, Xiwen Zeng, Yongliang Huang, Zongwu Ma, Jia Liu, Kunchao Han, Xiaoqiang Liu, Fan Yang, Huibin Tian, Xiuxiu Weng, Xiaoxue Zhang*,Weimin Wang. Relationship between hindgut microbes and feed conversion ratio in Hu sheep and microbial longitudinal development. J Anim Sci. 2023 Jan 3;101:skad322.(IF=3.3)

[7] Changchun Lin, Weimin Wang, Deyin Zhang, Kai Huang, Yukun Zhang, Xiaolong Li, Yuan Zhao, Liming Zhao, Jianghui Wang, Bubo Zhou, Jiangbo Cheng, Dan Xu, Wenxin Li, Xiaoxue Zhang*,Wenxin Zheng*. Analysis of liver miRNA in Hu sheep with different residual feed intake. Front Genet. 2023 Oct 19;14:1113411. (IF=3.7)

[8] Xiaolong Li, Lvfeng Yuan, Weimin Wang, Deyin Zhang, Yuan Zhao, Jiangbo Chen, Dan Xu, Liming Zhao, Fadi Li, Xiaoxue Zhang*.Whole genome re-sequencing reveals artificial and natural selection for milk traits in East Friesian sheep. Front Vet Sci. 2022 Oct 18;9:1034211.(IF=3.2)

[9] Rui Zhai, Weimin Wang, Deyin Zhang, Xiaolong Li, Yukun Zhang, Yuan Zhao, Liming Zhao, Jianghui Wang, Dan Xu, Jiangbo Cheng, Wenxin Li, Bubo Zhou, Changchun Lin, Xiwen Zeng, Xiaobin Yang, Zongwu Ma, Jia Liu, Panpan Cui, XiaoXue Zhang*. Novel polymorphism at KLF15 gene and its association with growth traits in Hu sheep. Anim Biotechnol. 2023 Dec;34(8):3287-3293. (IF=3.7)

[10] Xiwen Zeng, Weimin Wang, Deyin Zhang, Xiaolong Li, Yukun Zhang , Yuan Zhao, Liming Zhao, Jianghui Wang, Dan Xu, Jiangbo Cheng, Wenxin Li, Bubo Zhou, Changchun Lin, Xiaobin Yang, Rui Zhai, Zongwu Ma, Jia Liu, Panpan Cui, Xiuxiu Weng, Weiwei Wu, Xiaoxue Zhang*, Wenxin Zheng*. Polymorphism and expression level of the FADS3 gene and associated with the growth traits in Hu sheep. Anim Biotechnol. 2023 Dec;34(9):4793-4802. (IF=3.7)

[11] Panpan Cui , Weimin Wang, Deyin Zhang, Chong Li, Yongliang Huang, Zongwu Ma, Xiaojuan Wang, Liming Zhao, Yukun Zhang, Xiaobin Yang, Dan Xu, Jiangbo Cheng, Xiaolong Li, Xiwen Zeng, Yuan Zhao, Wenxin Li, Jianghui Wang, Changchun Lin, Bubo Zhou, Jia Liu, Rui Zhai, Xiaoxue Zhang*. Identification of TRAPPC9 and BAIAP2 Gene Polymorphisms and Their Association with Fat Deposition-Related Traits in Hu Sheep. Front Vet Sci. 2022 Jul 5;9:928375. (IF=3.2)

[12] Zongwu Ma, Weimin Wang, Deyin Zhang Yukun Zhang, Yuan Zhao, Xiaolong Li, Liming Zhao, Changchun Lin, Jianghui Wang, Bubo Zhou, Jiangbo Cheng, Dan Xu, Wenxin Li, Xiaobin Yang, Yongliang Huang, Panpan Cui, Jia Liu, Xiwen Zeng, Rui Zhai, Xiaoxue Zhang* .Ovine RAP1GAP and rBAT gene polymorphisms and their association with tail fat deposition in Hu sheep. Front Vet Sci. 2022 Aug 25;9:974513.(IF=3.2)

[13] Jianghui Wang, Yukun Zhang, Xiaojuan Wang, Fadi Li, Deyin Zhang, Xiaolong Li, Yuan Zhao, Liming Zhao, Dan Xu, Jiangbo Cheng, Wenxin Li, Changchun Lin, Xiaobin Yang, Rui Zhai, Xiwen Zeng, Panpan Cui, Zongwu Ma, Jia Liu, Xiaoxue Zhang*, Weimin Wang*. Association between rumen microbiota and marbling grade in Hu sheep. Front Microbiol. 2022 Sep 21;13:978263. (IF=5.2)

[14] Jianghui Wang, Xiaojuan Wang, WeiminWang, Fadi Li, Deyin Zhang, Xiaolong Li, Yukun Zhang, Yuan Zhao, Liming Zhao, Dan Xu, Jiangbo Cheng, Wenxin Li, Bubo Zhou, Changchun Lin, Xiaobin Yang, Rui Zhai, Xiwen Zeng, Xiaoxue Zhang*. Molecular characterization and expression of RPS23 and HPSE and their association with hematologic parameters in sheep. Gene. 2022 Aug 30; 837:146654. (IF=3.5)

[15] Changchun Lin, Weimin Wang, Deyin Zhang, Kai Huang, Xiaolong Li, Yukun Zhang, Yuan Zhao, Jianghui Wang, Bubo Zhou, Jiangbo Cheng, Dan Xu, Wenxin Li, Liming Zhao, Zongwu Ma, Xiaobin Yang, Yongliang Huang, Panpan Cui, Jia Liu, Xiwen Zeng, Rui Zhai, Landi Sun, Xiuxiu Weng, Weiwei Wu, Xiaoxue Zhang*, Wenxin Zheng*. Polymorphisms in SHISA3 and RFC3 genes and their association with feed conversion ratio in Hu sheep. Front Vet Sci. 2023 Jan 5;9:1010045. (IF=3.2)

[16] Liming Zhao, Weimin Wang, Xiaojuan Wang, Deyin Zhang, Xiaolong Li, Yuan Zhao, Yukun Zhang, Dan Xu, Jiangbo Cheng, Jianghui Wang, Wenxin Li, Changchun Lin, Weiwei Wu, Xiaoxue Zhang*, Wenxin Zheng*. Identification of SNPs and expression patterns of ALB, AHSG and GC genes and their association with growth traits in Hu sheep. Gene vol. 853 (2023): 147100.(IF=3.5)

[17] Liming Zhao, Deyin Zhang, Xiaolong Li, Yukun Zhang, Yuan Zhao, Dan Xu, Jiangbo Cheng, Jianghui Wang, Wenxin Li, Changchun Lin, Xiaobin Yang, Zongwu Ma, Panpan Cui, Xiaoxue Zhang*, Weimin Wang*. Comparative proteomics reveals genetic mechanisms of body weight in Hu sheep and Dorper sheep. J Proteomics. 2022 Sep 15:267:104699. (IF=3.3)

[18] Xiaobin Yang, Weimin Wang, Xiaojuan Wang, Deyin Zhang, Xiaolong Li, Yukun Zhang, Yuan Zhao, Liming Zhao, Jianghui Wang, Dan Xu, Jiangbo Cheng, Wenxin Li, Bubo Zhou, Changchun Lin, Xiwen Zeng, Rui Zhai, Zongwu Ma, Jia Liu, Panpan Cui, Xiaoxue Zhang*.Polymorphism in ovine ADCY8 gene and its association with residual feed intake in Hu sheep. Anim Biotechnol. 2023 Dec;34(8):3355-3362. (IF=3.7)

[19] Xiaobin Yang, Weimin Wang, Deyin Zhang, Xiaolong Li, Yukun Zhang, Yuan Zhao, Liming Zhao, Jianghui Wang, Dan Xu, Jiangbo Cheng, Wenxin Li, Bubo Zhou, Changchun Lin, Xiwen Zeng, Rui Zhai, Zongwu Ma, Jia Liu, Panpan Cui, and Xiaoxue Zhang*. Genetic polymorphism of the ovine MAP3K5 gene and its association with body size traits in Hu sheep of China. Arch. Anim. Breed., 66, 71–79, 2023. (IF=1.6)

[20] Dan Xu, Xiaojuan Wang, Weimin Wang, Deyin Zhang, Xiaolong Li, Yukun Zhang, Yuan Zhao, Jiangbo Cheng, Liming Zhao, Jianghui Wang, Changchun Lin, Xiaobin Yang, Xiuxiu Weng, Xiaoxue Zhang*, Wenxin Zheng*.Detection of single nucleotide polymorphism in HTR4 and its relationship with growth traits in sheep. Anim Biotechnol. 2023 Dec;34(9):4600-4607. (IF=3.7)

[21] Jiangbo Cheng, Weimin Wang, Deyin Zhang, Yukun Zhang, Xiaolong Li, Yuan Zhao, Dan Xu, Liming Zhao, Wenxin Li, Jianghui Wang, Bubo Zhou, Changchun Lin, Xiaobin Yang, Xiaoxue Zhang* . Identification of polymorphic loci in OSMR and GHR genes and analysis of their association with growth traits in sheep, Animal Biotechnology,2023 Dec;34(7):2546-2553. (IF=3.7)

[22] Jiangbo Cheng, Weimin Wang, Deyin Zhang, Yukun Zhang, Qizhi Song, Xiaolong Li, Yuan Zhao, Dan Xu, Liming Zhao, Wenxin Li, Jianghui Wang, Bubo Zhou, Changchun Lin 1 and Xiaoxue Zhang*. Distribution and Difference of Gastrointestinal Flora in Sheep with Different Body Mass Index, Animals (Basel). 2022 Mar 30;12(7):880. (IF=3)

[23] Xiaoxue Zhang,Weimin Wang, Futao Mo, Yongfu La, Chong Li, Fadi Li. Association of residual feed intake with growth and slaughtering performance, blood metabolism, and body composition in growing lambs. Sci Rep. 2017 Oct 4;7(1):12681. (IF=4.295)

2. 授权专利（排名第一）

[1] 一种与绵羊阶段体重性状相关的分子标记及其应用，国家发明专利， 2024

[2] 一种与绵羊尾脂沉积相关的分子标记及其应用，国家发明专利， 2024

[3] 一种与湖羊体重相关的分子标记及其应用，国家发明专利，2024

[4] 与绵羊生长性状相关的分子标记、其检测方法及应用，国家发明专利，2024

[5] RYR2基因作为影响绵羊饲料转化率的分子标记及其应用，国家发明专利，2020

[6] 一种可移动羊用体重和体尺测定装置，实用新型专利，2020

[7] 一种单栏羊舍的体重测定装置，实用新型专利，2020

3. 获奖

[1] 湖羊选育扩繁和高效利用关键技术研究与应用，甘肃省科技进步一等奖，2022，第7

[2] 羔羊早期培育关键技术研发与应用，甘肃省科技进步三等奖，2021，第3

[3] 高繁殖力优质肉羊新品种培育及产业化开发，甘肃省科技进步二等奖，2016，第7

4. 著作

[1] 《动物遗传育种学》副主编，甘肃科学技术出版社，2020

[2] 《畜牧学基础》，参编，甘肃科学技术出版社，2017